Protective effects of Mentha haplocalyx ethanol extract (MH) in a mouse model of allergic asthma.
Phytother Res
; 25(6): 863-9, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21108485
ABSTRACT
Mentha haplocalyx Briq., a commonly used herb in traditional Oriental medicine, has a variety of known pharmacological properties. However, neither the protective effects of Mentha haplocalyx ethanol extract (MH) against inflammation of the airway in an asthmatic model nor the mechanisms involved, have previously been reported. In the present study, an ovalbumin (OVA)-induced mouse model of allergic asthma was used to investigate whether MH was effective against the disease through regulation of airway inflammation. The MH treatment significantly inhibited increases in immunoglobulin (Ig) E and T-helper 2 (Th2)-type cytokines such as IL-4 and IL-5 in bronchoalveolar lavage fluid (BALF) and lung tissue. Inflammatory cell infiltration of the airway in mice treated with MH was effectively alleviated when compared with infiltration seen in the OVA-induced group. These data indicated that decreased cytokine levels are the result of the decreased number of invaded leukocytes. Also, the generation of reactive oxygen species (ROS) in BALF was diminished by MH treatment. Taken together, these findings indicate that the administration of MH may have potential therapeutic value in the treatment of inflammatory disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Medicamentos Herbarios Chinos
/
Antiasmáticos
/
Mentha
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2011
Tipo del documento:
Article