Interleukin-33: a novel mediator with a role in distinct disease pathologies.
J Intern Med
; 269(1): 29-35, 2011 Jan.
Article
en En
| MEDLINE
| ID: mdl-21158975
ABSTRACT
Interleukin-33 (IL-33) is a novel member of IL-1 cytokine family. It can act both as a nuclear factor and as a soluble mediator; however, the precise role of IL-33 within the nucleus is still not clear. As a cytokine, IL-33 is suggested to function as an alarmin that is released upon endothelial or epithelial cell damage. As such, IL-33 targets multiple cell types thereby alerting the immune system to endogenous trauma such as physical stress or infection. However, a dysregulated release of IL-33 has a potential to drive distinct pathologies. In this review, we discuss the contribution of IL-33 to the pathophysiology of asthma, arthritis, obesity and atherosclerosis as well as the potential of IL-33 for therapeutic intervention.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Interleucinas
/
Inflamación
Límite:
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article