Long-term tolerability of etoricoxib in different types of NSAID-intolerant subjects.
Eur Ann Allergy Clin Immunol
; 42(6): 216-20, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-21287945
ABSTRACT
BACKGROUND:
Non-steroidal anti-inflammatory drugs (NSAIDs) are a frequent cause of hypersensitivity reactions, therefore, in clinical practice, it's important to find safe and effective substances.OBJECTIVE:
To evaluate the tolerability of etoricoxib and its subsequent actual use and safety at home.METHODS:
Etoricoxib tolerance was assessed by single-blind-placebo-controlled oral challenges and its subsequent use was checked by a standardized telephone call. The test was performed in 139 subjects (83 single NSAID reactors and 56 multiple NSAID reactors).RESULTS:
The drug was not tolerated in 4 cases (2.8%) causing wheals on the face area in 3 single reactors and a severe generalised reaction occurring three hours after the intake of a therapeutic dose in a multiple reactor. The phone calls showed that 64 (52.8%) patients did not take etoricoxib, mostly due to the fear of adverse effects; in 5 cases (4.2%), the practitioner prescribed a different NSAIDs. Only 52 (43%) subjects took etoricoxib after oral challenges; all tolerated the drug but 2 single reactors, who reported a very mild labial oedema.CONCLUSION:
Our study confirmed the good long-term tolerability of etoricoxib in patients with a history of hypersensitivity to other NSAIDs without differences between single and multiple reactors. Nonetheless, in NSAID-intolerant subjects this drug should be first challenged in specialised centres due to the risk ofsevere reactions.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Piridinas
/
Sulfonas
/
Antiinflamatorios no Esteroideos
/
Hipersensibilidad a las Drogas
/
Inhibidores de la Ciclooxigenasa 2
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2010
Tipo del documento:
Article