Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1.
J Neurosci
; 31(9): 3309-19, 2011 Mar 02.
Article
en En
| MEDLINE
| ID: mdl-21368042
ABSTRACT
Dendrites and axons are two major neuronal compartments with differences that are critical for neuronal functions. To learn about the differential regulation of dendritic and axonal development, we conducted a genetic screen in Drosophila and isolated the dendritic arbor reduction 1 (dar1) mutants, which display defects in dendritic but not axonal growth. The dar1 gene encodes a novel transcription regulator in the Krüppel-like factor family. Neurons lacking dar1 function have severely reduced growth of microtubule- but not F-actin-based dendritic branches. In contrast, overexpression of Dar1 dramatically increased the growth of microtubule-based dendritic branches. Our results suggest that Dar1 promotes dendrite growth in part by suppressing the expression of the microtubule-severing protein Spastin. Our study thus uncovers a novel transcriptional program for microtubule regulation that preferentially controls dendrite growth.
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1
Banco de datos:
MEDLINE
Asunto principal:
Axones
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Adenosina Trifosfatasas
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Receptores de Neuropéptido
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Proteínas de Drosophila
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Dendritas
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Receptores Acoplados a Proteínas G
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Factores de Transcripción de Tipo Kruppel
Límite:
Animals
Idioma:
En
Año:
2011
Tipo del documento:
Article