The effect of cell-ECM adhesion on signalling via the ErbB family of growth factor receptors.
Biochem Soc Trans
; 39(2): 568-73, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21428941
ABSTRACT
Integrins and growth factor receptors of the ErbB family are involved in the regulation of cellular interactions with the extracellular microenvironment. Cross-talk between these two groups of transmembrane receptors is essential for cellular responses and can be regulated through the formation of multimolecular complexes. Tetraspanins as facilitators and building blocks of specialized microdomains may be involved in this process. In the present study, we demonstrated that, in contrast with previous reports, integrin-mediated adhesion did not stimulate ligand-independent activation of ErbB receptors in epithelial cells. However, integrin-dependent adhesion potentiated ligand-induced activation of EGFR (epidermal growth factor receptor) and ErbB2 and facilitated receptor homo- and hetero-dimerization. The actin cytoskeleton appeared to play a critical role in this phenomenon.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Oncogénicas v-erbB
/
Matriz Extracelular
Límite:
Animals
/
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article