Actin depolymerizing effect of trisoxazole-containing macrolides.
Bioorg Med Chem Lett
; 21(11): 3198-201, 2011 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-21550239
ABSTRACT
Oxazole-containing macrolides (1-5) isolated from the marine sponge Chondrosia corticata were evaluated for their actin depolymerizing activities by monitoring fluorescent intensity of pyrene F-actin. These studies led to the identification of (19Z)-halichondramide (5) as a new actin depolymerizing agent. The actin depolymerizing activity by (19Z)-halichondramide (5) was four times more potent than that of halichondramide (1). Compounds 1 and 5 also have potent antifungal activity. The preliminary structure-activity relationship of these compounds is described to elucidate the essential structural requirements.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oxazoles
/
Poríferos
/
Macrólidos
Límite:
Animals
Idioma:
En
Año:
2011
Tipo del documento:
Article