Glycobiology and the growth plate: current concepts in multiple hereditary exostoses.
J Pediatr Orthop
; 31(5): 577-86, 2011.
Article
en En
| MEDLINE
| ID: mdl-21654469
ABSTRACT
BACKGROUND:
Multiple hereditary exostoses, also termed as multiple osteochondromas, is a heritable disorder of connective tissue with primarily orthopaedic clinical manifestations. Understanding of its biological underpinnings has been advanced on a variety of fronts in recent years.METHODS:
The multifaceted literature regarding osteochondromagenesis and the major clinical challenges in patients with multiple osteochondromas were reviewed.RESULTS:
Consideration of recent advances in molecular biology, biochemistry, and animal modeling of osteochondroma pathogenesis yields a unified model.CONCLUSIONS:
Mechanistic details and therapeutic targets have yet to be elucidated, but the general biology of osteochondroma formation is increasingly clear, as well as its implications in the orthopaedic clinical setting.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Exostosis Múltiple Hereditaria
/
Glicómica
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Placa de Crecimiento
Límite:
Animals
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Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article