Treatment of chancroid with spectinomycin or co-trimoxazole.
Clin Ther
; 12(3): 200-5, 1990.
Article
en En
| MEDLINE
| ID: mdl-2165860
ABSTRACT
Chancroid, the third most prevalent venereal disease in Thailand, was treated with a single 2-gm dose of spectinomycin, or two tablets of co-trimoxazole (trimethoprim-sulfamethoxazole) twice daily for seven days. The differences in cure rates between the two groups were statistically significant. The chancroidal ulcers were cured in 93.7% of 175 patients treated with spectinomycin, and in 48.2% of 168 co-trimoxazole-treated patients (P less than 0.01). The in vitro susceptibility of Haemophilus ducreyi to spectinomycin was 4 to 16 micrograms/ml and to co-trimoxazole 32 micrograms/ml or higher. Thus we found that a single-dose regimen of spectinomycin was significantly more effective than the standard seven-day regimen of co-trimoxazole for the treatment of chancroid.
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Banco de datos:
MEDLINE
Asunto principal:
Chancroide
/
Combinación Trimetoprim y Sulfametoxazol
/
Espectinomicina
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1990
Tipo del documento:
Article