Silacarboxylic acids as efficient carbon monoxide releasing molecules: synthesis and application in palladium-catalyzed carbonylation reactions.
J Am Chem Soc
; 133(45): 18114-7, 2011 Nov 16.
Article
en En
| MEDLINE
| ID: mdl-22014278
ABSTRACT
Silacarboxylic acids have been demonstrated to be easy to handle, air-stable carbon monoxide precursors. Different silacarboxylic acids were synthesized from the corresponding chlorosilanes and carbon dioxide, and their decarbonylation, upon treatment with an array of activators, was evaluated. The release of CO from crystalline MePh(2)SiCO(2)H proved to be highly efficient, and it was successfully applied in a selection of palladium-catalyzed carbonylative couplings using near-stoichiometric quantities of carbon monoxide precursor. Finally, the synthesis of MePh(2)Si(13)CO(2)H and its application in carbonyl labeling of two bioactive compounds was demonstrated.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Paladio
/
Silanos
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Monóxido de Carbono
/
Ácidos Carboxílicos
Idioma:
En
Año:
2011
Tipo del documento:
Article