Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum.
Mol Cell Proteomics
; 11(2): M111.010645, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-22023809
ABSTRACT
Differential expression of ligands in the human malaria parasite Plasmodium falciparum enables it to recognize different receptors on the erythrocyte surface, thereby providing alternative invasion pathways. Switching of invasion from using sialated to nonsialated erythrocyte receptors has been linked to the transcriptional activation of a single parasite ligand. We have used quantitative proteomics to show that in addition to this single known change, there are a significant number of changes in the expression of merozoite proteins that are regulated independent of transcription during invasion pathway switching. These results demonstrate a so far unrecognized mechanism by which the malaria parasite is able to adapt to variations in the host cell environment by post-transcriptional regulation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Proteínas Protozoarias
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Malaria Falciparum
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Proteómica
/
Eritrocitos
/
Merozoítos
Límite:
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article