Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.

Mathew, Bini; Srivastava, Shefali; Ross, Larry J; Suling, William J; White, E Lucile; Woolhiser, Lisa K; Lenaerts, Anne J; Reynolds, Robert C

Mathew, Bini; Srivastava, Shefali; Ross, Larry J; Suling, William J; White, E Lucile; Woolhiser, Lisa K; Lenaerts, Anne J; Reynolds, Robert C.

Afiliación

Mathew B; Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA.

Bioorg Med Chem ; 19(23): 7120-8, 2011 Dec 01.

Article en En | MEDLINE | ID: mdl-22024272

ABSTRACT

ABSTRACT

A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H(37)Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity.

Asunto(s)

Antituberculosos/farmacología; Proteínas Bacterianas/antagonistas & inhibidores; Proteínas del Citoesqueleto/antagonistas & inhibidores; Pirazinas/farmacología; Tiazinas/farmacología; Animales; Antituberculosos/síntesis química; Antituberculosos/química; Modelos Animales de Enfermedad; Humanos; Ratones; Ratones Endogámicos C57BL; Mycobacterium tuberculosis/química; Mycobacterium tuberculosis/efectos de los fármacos; Mycobacterium tuberculosis/metabolismo; Pirazinas/síntesis química; Pirazinas/química; Piridinas/síntesis química; Piridinas/química; Piridinas/farmacología; Pirimidinas/síntesis química; Pirimidinas/química; Pirimidinas/farmacología; Relación Estructura-Actividad; Tiazinas/síntesis química; Tiazinas/química

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazinas / Tiazinas / Proteínas Bacterianas / Proteínas del Citoesqueleto / Antituberculosos Límite: Animals / Humans Idioma: En Año: 2011 Tipo del documento: Article

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