Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse.
J Clin Microbiol
; 50(4): 1449-51, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22205791
ABSTRACT
Using a newly developed Plasmodium vivax merozoite surface protein 1 gene (Pvmsp1) heteroduplex tracking assay, we genotyped 107 P. vivax infections in individuals from Cambodia, 45 of whom developed recurrent parasitemia within 42 days. The majority of isolates were polyclonal, but recurrent parasitemias displayed fewer variants compared to initial parasitemias. Two Pvmsp1 gene variants occurred more frequently in the initial genotypes of those who developed recurrent parasitemia, representing the first time P. vivax variants associated with a higher risk of relapse have been described.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium vivax
/
Malaria Vivax
/
Proteína 1 de Superficie de Merozoito
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article