[Regenerative therapy using allogeneic mesenchymal stem cells].
Nihon Rinsho
; 69(12): 2121-7, 2011 Dec.
Article
en Ja
| MEDLINE
| ID: mdl-22242308
ABSTRACT
The use of mesenchymal stem cells (MSC) for tissue and organ regeneration offers advantages because the MSC contain multipotent progenitor cells and reported to be immunoprivileged as well as immunosuppressive. Therefore, cell therapy with allogeneic MSC has been reported as a promising treatment for severe acute graft versus host disease (GVHD). We reported a pilot study for GVHD treatments using a small number of allogeneic MSC. We also reported that MSC can show osteogenic differentiation capability when implanted in vivo as well as cultured in vitro. Based on these findings, we attempted to use allogeneic MSC for the treatment of genetic disorder of hypophosphatasia patient. Present paper summarizes our clinical experiences of allogeneic MSC for the purpose of regenerative medicine.
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Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Células Madre Mesenquimatosas
Límite:
Animals
/
Humans
Idioma:
Ja
Año:
2011
Tipo del documento:
Article