Perspectives on the discovery of small-molecule modulators for epigenetic processes.
J Biomol Screen
; 17(5): 555-71, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22392809
ABSTRACT
Epigenetic gene regulation is a critical process controlling differentiation and development, the malfunction of which may underpin a variety of diseases. In this article, we review the current landscape of small-molecule epigenetic modulators including drugs on the market, key compounds in clinical trials, and chemical probes being used in epigenetic mechanistic studies. Hit identification strategies for the discovery of small-molecule epigenetic modulators are summarized with respect to writers, erasers, and readers of histone marks. Perspectives are provided on opportunities for new hit discovery approaches, some of which may define the next generation of therapeutic intervention strategies for epigenetic processes.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Epigénesis Genética
/
Descubrimiento de Drogas
/
Ensayos Analíticos de Alto Rendimiento
Límite:
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article