CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis.
J Neuroimmunol
; 249(1-2): 1-7, 2012 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-22626443
ABSTRACT
The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle.
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1
Banco de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
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Linfocitos T CD4-Positivos
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Adyuvantes Inmunológicos
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Lipopolisacáridos
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Miastenia Gravis Autoinmune Experimental
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Animals
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En
Año:
2012
Tipo del documento:
Article