[Effects of dietary fat level on the xenobiotic metabolism enzymes activity and antioxidant enzymes in rats].
Vopr Pitan
; 81(1): 24-9, 2012.
Article
en Ru
| MEDLINE
| ID: mdl-22642161
ABSTRACT
Male Wistar rats received fat-free diet or diets containing 5, 10 and 30% of fat (sunflower oil + lard, 11) for 4 weeks. The direct relationship between dietary fat level and ethoxyresorufin O-dealkylase activity of CYP1A1, methoxyresorufin O-dealkylase activity of CYP1A2, pentoxyresorufin O-dealkylase activity of CYP2B1 and testosterone 6beta-hydroxylase activity of CYP3A was found. Activities of key enzymes of phase II xenobiotic metabolism (total activity of glutathione transferase, activity of UDP-glucuronosyle transferase) and antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase, paraoxonase-1 and heme oxygenase-1) also increased with higher dietary fat level.
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Banco de datos:
MEDLINE
Asunto principal:
Aceites de Plantas
/
Microsomas Hepáticos
/
Grasas de la Dieta
/
Hidrocarburo de Aril Hidroxilasas
/
Antioxidantes
Idioma:
Ru
Año:
2012
Tipo del documento:
Article