Chemical characterization of the smallest S-nitrosothiol, HSNO; cellular cross-talk of H2S and S-nitrosothiols.
J Am Chem Soc
; 134(29): 12016-27, 2012 Jul 25.
Article
en En
| MEDLINE
| ID: mdl-22741609
ABSTRACT
Dihydrogen sulfide recently emerged as a biological signaling molecule with important physiological roles and significant pharmacological potential. Chemically plausible explanations for its mechanisms of action have remained elusive, however. Here, we report that H(2)S reacts with S-nitrosothiols to form thionitrous acid (HSNO), the smallest S-nitrosothiol. These results demonstrate that, at the cellular level, HSNO can be metabolized to afford NO(+), NO, and NO(-) species, all of which have distinct physiological consequences of their own. We further show that HSNO can freely diffuse through membranes, facilitating transnitrosation of proteins such as hemoglobin. The data presented in this study explain some of the physiological effects ascribed to H(2)S, but, more broadly, introduce a new signaling molecule, HSNO, and suggest that it may play a key role in cellular redox regulation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
S-Nitrosotioles
/
Sulfuro de Hidrógeno
/
Óxido Nítrico
Límite:
Humans
Idioma:
En
Año:
2012
Tipo del documento:
Article