Inflammatory fibroid polyp in the duodenum of a common marmoset (Callithrix jacchus).
Toxicol Pathol
; 41(1): 80-5, 2013 Jan.
Article
en En
| MEDLINE
| ID: mdl-22786945
ABSTRACT
A 32-month-old male common marmoset had a firm and white-colored mass in the duodenal wall. The cut surface was smooth and grayish white in color. Histologically, the mass consisted of a proliferation of spindle cells with an oval to spindle-shaped nucleus and scant eosinophilic cytoplasm in a loose myxoid or fibrotic background. Most of the lesion displayed no specific growth pattern whereas some of the cells concentrated around the vessels and created an onion-bulb structure. Additionally, marked inflammatory cellular infiltration, mainly eosinophils, was observed throughout the lesion. Immunohistochemically, the spindle cells were positive for vimentin, α-smooth muscle actin, fascin, and cyclin D1, and negative for S-100, factor VIII-related antigen, and c-kit. These histological and immunohistochemical features did not meet any differential diagnoses such as gastrointestinal stromal tumor, inflammatory myofibroblastic tumor, solitary fibrous tumor/hemangiopericytoma, smooth muscle tumor, schwannoma, and hemangiosarcoma. Collectively, the authors diagnosed the mass as a lesion that corresponded to an inflammatory fibroid polyp (IFP) in humans. IFP is defined as a mesenchymal proliferation composed of spindle stromal cells, small blood vessels, and inflammatory cells, particularly eosinophils, and is currently classified as a nonneoplastic lesion. To the best of our knowledge, this is the first case of spontaneous IFP in nonhuman primates.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Callithrix
/
Pólipos Intestinales
/
Enfermedades Duodenales
/
Enfermedades de los Monos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article