Antiischemic activity of new domestic antioxidant 3-hydroxypyridine etoxidol derivative.
Bull Exp Biol Med
; 152(5): 583-6, 2012 Mar.
Article
en En, Ru
| MEDLINE
| ID: mdl-22803139
ABSTRACT
Experiments on rats with myocardium infarction showed that intravenous administration of etoxidol in a dose of 14.2 mg/kg restricted the size of necrosis area and reduced the ratio of necrosis/ischemia zones. The test compound reduced the risk of rhythm and conduction disturbances induced by administration of toxic epinephrine doses to the mice, and increased mouse survival. Etoxidol administered intravenously to cats with acute myocardial ischemia reduced epinephrine concentration and intensity of free radical oxidation in zones of myocardial lesions against the background of the increase in norepinephrine concentration and antioxidant activity in the myocardium. By antiischemic and antioxidant activity, etoxidol was superior to its structural analogue mexidol.
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Banco de datos:
MEDLINE
Asunto principal:
Piridinas
/
Corazón
/
Infarto del Miocardio
/
Necrosis
/
Antioxidantes
Límite:
Animals
Idioma:
En
/
Ru
Año:
2012
Tipo del documento:
Article