Purpurogemutantin and purpurogemutantidin, new drimenyl cyclohexenone derivatives produced by a mutant obtained by diethyl sulfate mutagenesis of a marine-derived Penicillium purpurogenum G59.

Fang, Shi-Ming; Cui, Cheng-Bin; Li, Chang-Wei; Wu, Chang-Jing; Zhang, Zhi-Jun; Li, Li; Huang, Xiao-Jun; Ye, Wen-Cai

Fang, Shi-Ming; Cui, Cheng-Bin; Li, Chang-Wei; Wu, Chang-Jing; Zhang, Zhi-Jun; Li, Li; Huang, Xiao-Jun; Ye, Wen-Cai.

Afiliación

Fang SM; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Cui CB; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li CW; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Wu CJ; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang ZJ; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Li L; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Huang XJ; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Ye WC; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Mar Drugs ; 10(6): 1266-1287, 2012 Jun.

Article en En | MEDLINE | ID: mdl-22822371

Asunto(s)

Antineoplásicos/química; Antineoplásicos/farmacología; Organismos Acuáticos/química; Penicillium/química; Penicillium/genética; Ésteres del Ácido Sulfúrico/química; Organismos Acuáticos/genética; Organismos Acuáticos/metabolismo; Productos Biológicos/química; Productos Biológicos/metabolismo; Productos Biológicos/farmacología; Línea Celular Tumoral; Dicroismo Circular/métodos; Ensayos de Selección de Medicamentos Antitumorales; Células HL-60; Células HeLa; Humanos; Células K562; Células MCF-7; Espectroscopía de Resonancia Magnética/métodos; Mutagénesis; Mutación; Penicillium/efectos de los fármacos; Penicillium/metabolismo

Palabras clave

DES mutagenesis; Penicillium purpurogenum; antitumor activity; marine-derived fungus; meroterpenoid; purpurogemutantidin; purpurogemutantin; sesquiterpene; structure determination

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Penicillium / Ésteres del Ácido Sulfúrico / Organismos Acuáticos / Antineoplásicos Límite: Humans Idioma: En Año: 2012 Tipo del documento: Article

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