Folding RNA/DNA hybrid duplexes.

ABSTRACT

MOTIVATION While there are numerous programs that can predict RNA or DNA secondary structures, a program that predicts RNA/DNA hetero-dimers is still missing. The lack of easy to use tools for predicting their structure may be in part responsible for the small number of reports of biologically relevant RNA/DNA hetero-dimers. RESULTS: We present here an extension to the widely used ViennaRNA Package (Lorenz et al., 2011) for the prediction of the structure of RNA/DNA hetero-dimers. AVAILABILITY: http//www.tbi.univie.ac.at/~ronny/RNA/vrna2.html CONTACT ronny@tbi.univie.ac.at, berni@bioinf.uni-leipzig.de SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.