Screening α-glucosidase inhibitors from mulberry extracts via DOSY and relaxation-edited NNR.
Talanta
; 97: 362-7, 2012 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-22841093
ABSTRACT
Inhibition of the α-glucosidase activity is a therapeutic approach for diabetes. In this study, an effective strategy for screening α-glucosidase inhibitors based on Nuclear magnetic resonance (NMR) techniques was developed to screen and identify α-glucosidase inhibitors from Mulberry leaf extract. As a result, deoxynojirimycin, as a potential α-glucosidase inhibitor, was found. The study suggested that our strategy was a powerful tool for screening and identification of α-glucosidase inhibitors in complex samples. Furthermore the interaction between α-glucosidase and its inhibitor was studied by NMR.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Espectroscopía de Resonancia Magnética
/
Morus
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Inhibidores Enzimáticos
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Inhibidores de Glicósido Hidrolasas
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Año:
2012
Tipo del documento:
Article