[Casein kinase 2, the versatile regulator of cell survival].
Mol Biol (Mosk)
; 46(3): 423-33, 2012.
Article
en Ru
| MEDLINE
| ID: mdl-22888632
ABSTRACT
Casein kinase 2 (CK2), a highly conservative, multifunctional serine/threonine protein kinase, is critically important for the regulation of a plethora of processes in eukaryotes, such as cell proliferation, differentiation and death. CK2 is expressed in all tissues; in particular, its amount and activity are elevated in tumor cells. Unlike many regulatory proteins CK2 permanently adopts an active conformation. Of the utmost importance are the anti-apoptotic functions of CK2. This protein kinase is capable of regulating cell survival at multiple levels including DNA repair, NF-kappaB, Wnt, PI3K/Akt and JAK-STAT signaling cascades, chaperones, activation of anti-apoptotic proteins and down-regulation of pro-apoptotic counterparts, in particular, caspases. The versatility of CK2-mediated phosphorylation ensures the survival of tumor cells exposed to stimuli that differ in the origin and mechanisms of cytotoxicity. This manifold mode of CK2-dependent survival makes this enzyme an important target for antitumor therapy.
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Banco de datos:
MEDLINE
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Quinasa de la Caseína II
/
Proteínas Reguladoras de la Apoptosis
/
Proteínas de Neoplasias
/
Neoplasias
Límite:
Humans
Idioma:
Ru
Año:
2012
Tipo del documento:
Article