Thermodynamic and structural effects of propranolol on DPPC liposomes.
Chem Phys Lipids
; 55(3): 331-7, 1990 Sep.
Article
en En
| MEDLINE
| ID: mdl-2289290
ABSTRACT
Some thermodynamic and structural aspects of propranolol-DPPC liposomes interaction were investigated by DSC and X-ray diffraction the lamellar arrangement of the lipid matrix remains intact even at high concentrations of the drug (until 11 drug/lipid molar ratio). However, the bilayer thickness increases significantly and the chains become perpendicular to the lamellar planes, for increasing drug content. At still higher propranolol concentrations a hexagonal phase occurs followed by a lamellar phase, in which the liposomes are destroyed. Moreover, the presence of propranolol has been found to impart fluidity to the lipid matrix.
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Banco de datos:
MEDLINE
Asunto principal:
Propranolol
/
1,2-Dipalmitoilfosfatidilcolina
/
Liposomas
Idioma:
En
Año:
1990
Tipo del documento:
Article