Prevalence of antiphospholipid antibodies in rheumatoid arthritis patients and relationship with disease activity.
Pol Arch Med Wewn
; 122(10): 480-6, 2012.
Article
en En
| MEDLINE
| ID: mdl-22910193
ABSTRACT
INTRODUCTION:
It is still unclear how important the presence of antiphospholipid antibodies (aPL) is in patients with rheumatoid arthritis (RA).OBJECTIVES:
The aim of the study was to assess the prevalence of selected aPL in RA patients and their correlation with the presence of markers for RA antibodies and with disease activity. PATIENTS ANDMETHODS:
The study group consisted of 97 patients with RA who had never been treated with biological agents. In all patients, serum anticardiolipin antibodies (aCL), antiß2glycoprotein I antibodies (aß2GPI), lupus anticoagulant (LAC), immunoglobulin M (IgM) rheumatoid factor (RF), and anticyclic citrullinated peptide antibodies (antiCCP) were measured and disease activity was assessed.RESULTS:
The presence of aPL was observed in 27 patients (27.8%) aCL in 20 patients (20.6%), aß2GPI in 12 patients (12.4%), and LAC in 1 patient (1%). Positive aCL of low or medium levels were detected in the IgM class in 11 patients (11.3%) and in the IgG class in 12 patients (12.5%). Positive aß2GPI of low and medium levels were found only in the IgM class. The presence of LAC was associated with aCLIgM and aß2GPIIgM. A significant correlation was observed between the presence of antiCCP and different types of aPL. There was no correlation between aPL and IgMRF or disease activity markers.CONCLUSIONS:
The prevalence of aPL in patients with RA is relatively high. There is a relationship between the prevalence of aPL and antiCCP-serological marker of RA, but there are no significant correlations between disease activity and the presence of aPL.
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Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Anticuerpos Antifosfolípidos
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2012
Tipo del documento:
Article