Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells.
Small
; 9(9-10): 1691-5, 2013 May 27.
Article
en En
| MEDLINE
| ID: mdl-22996965
ABSTRACT
Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células de la Médula Ósea
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División Celular
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Regulación hacia Arriba
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Nanotubos de Carbono
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Neoplasias Pulmonares
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article