A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer.
Nat Genet
; 44(12): 1326-9, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-23104005
ABSTRACT
In Western countries, prostate cancer is the most prevalent cancer of men and one of the leading causes of cancer-related death in men. Several genome-wide association studies have yielded numerous common variants conferring risk of prostate cancer. Here, we analyzed 32.5 million variants discovered by whole-genome sequencing 1,795 Icelanders. We identified a new low-frequency variant at 8q24 associated with prostate cancer in European populations, rs188140481[A] (odds ratio (OR) = 2.90; P(combined) = 6.2 × 10(-34)), with an average risk allele frequency in controls of 0.54%. This variant is only very weakly correlated (r(2) ≤ 0.06) with previously reported risk variants at 8q24, and its association remains significant after adjustment for all known risk-associated variants. Carriers of rs188140481[A] were diagnosed with prostate cancer 1.26 years younger than non-carriers (P = 0.0059). We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Adenocarcinoma
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Mutación
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Año:
2012
Tipo del documento:
Article