New insights in mitochondrial calcium handling by sodium/calcium exchanger.
Adv Exp Med Biol
; 961: 203-9, 2013.
Article
en En
| MEDLINE
| ID: mdl-23224881
ABSTRACT
Mitochondria are now recognized as one of the main intracellular calcium-storing organelles which play a key role in the intracellular calcium signalling. Indeed, besides performing oxidative phosphorylation, mitochondria are able to sense and shape calcium (Ca(2+)) transients, thus controlling cytosolic Ca(2+) signals and Ca(2+)-dependent protein activity. It has been well established for many years that mitochondria have a huge capacity to accumulate calcium. While the physiological significance of this pathway was hotly debated until relatively recently, it is now clear that the ability of mitochondria in calcium handling is a ubiquitous phenomenon described in every cell system in which the issue has been addressed.In this chapter, we will review the molecular mechanisms involved in the regulation of mitochondrial calcium cycling in physiological conditions with particular regard to the role played by the mitochondrial Na(+)/Ca(2+) exchanger.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fosforilación Oxidativa
/
Calcio
/
Intercambiador de Sodio-Calcio
/
Señalización del Calcio
/
Proteínas Mitocondriales
Límite:
Animals
/
Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article