Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.
Antimicrob Agents Chemother
; 57(3): 1513-7, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-23263008
ABSTRACT
Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Acetolactato Sintasa
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Pseudomonas aeruginosa
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Compuestos de Sulfonilurea
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Proteínas Bacterianas
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Burkholderia pseudomallei
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Acinetobacter baumannii
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Herbicidas
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article