Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(4): 996-1000, 2013 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-23312944
ABSTRACT
Structure-activity relationship (SAR) of a novel, potent and metabolically stable series of benzo [3.2.1] bicyclic sulfonamide-pyrazoles as γ-secretase inhibitors are described. Compounds that are efficacious in reducing the cortical Aßx-40 levels in FVB mice via oral dose, as well as those with high selectivity over Notch, are highlighted.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pirazoles
/
Sulfonamidas
/
Secretasas de la Proteína Precursora del Amiloide
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article