Valved shunt as a treatment for obstructive uropathy: does pressure make a difference?
Pediatr Surg Int
; 29(4): 381-6, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23392914
ABSTRACT
PURPOSE:
A valved ventriculo-peritoneal shunt (V-P shunt) as a vesico-amniotic shunt (V-A shunt) preserves the filling/emptying cycle and normal bladder development in fetal lambs with bladder outlet obstruction. The optimal pressure for such shunts is unknown. MATERIALS ANDMETHODS:
We created obstructive uropathy in 60-day gestation fetal lambs. A V-A shunt was placed 3 weeks later, using a low-pressure (Group L 15-54 mmH2O) or a high-pressure (Group H 95-150 mmH2O) V-P shunt. We included non-shunted (obstructive uropathy, Group O) and control lambs (Group C). All were delivered at 130 days. Bladder volumes, bladder thickness, renal and bladder histology were compared.RESULTS:
Seventeen lambs had an obstructive uropathy created. Five Group L (four survived), four Group H (three survived) and five Group O survived. Body weight and crown-to-rump lengths of the three groups were not significantly different. Group H lambs had a dilated urachus, urinary ascites and severe ureteral dilatation similar to Group O lambs. There were four Group C lambs. Bladder volume was 10, 15 and 1,150 ml in Group H, 115 ± 67.9 ml in Group L, 128 ± 99.8 ml in Group O and 24.5 ± 3.84 ml in Group C. Unlike Group O lambs, Group L did not have urinary ascites, urinomas or renal dysplasia.CONCLUSION:
Low-pressure shunts preserved both bladder volume and renal development. High-pressure shunts did neither.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Obstrucción del Cuello de la Vejiga Urinaria
/
Derivación Ventriculoperitoneal
/
Terapias Fetales
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article