Your browser doesn't support javascript.
loading
Analysis of metallothionein and vimentin immunoreactivity in pharyngeal squamous cell carcinoma and its microenvironment.
Dutsch-Wicherek, Magdalena; Lazar, Agata; Tomaszewska, Romana; Kazmierczak, Wojciech; Wicherek, Lukasz.
Afiliación
  • Dutsch-Wicherek M; Outpatient Unit of Otolaryngology, Lukaszczyk Oncological Center, Bydgoszcz, Poland. mowicher@gmail.com
Cell Tissue Res ; 352(2): 341-9, 2013 May.
Article en En | MEDLINE | ID: mdl-23397427
ABSTRACT
Metallothionein (MT) has been shown to have pro-proliferative anti-apoptotic activity and to be involved in microenvironment remodeling. The aim of this study has been to determine whether the changes in MT and vimentin immunoreactivity observed in cancer and its microenvironment are related to the local spread of the disease. The immunoreactivity levels of both MT and vimentin were evaluated together with CD56 and CD57 antigens in 49 tissue samples taken from patients with squamous cell carcinoma originating from the palatine tonsils and in 20 tissue samples derived from patients with chronic tonsillitis (the reference group). MT immunoreactivity levels were statistically significantly higher in the tissue samples from squamous cell carcinoma than in those of the reference group and also higher in the squamous cell carcinoma samples compared with the stromal samples. Moreover, stromal fibroblasts exhibited high vimentin and MT immunoreactivity levels. Statistically significantly higher MT immunoreactivity levels within the tumor cells were identified in patients with the presence of lymph node metastases in contrast to those patients without such metastases. Vimentin was detected in both the tumor and the stromal tissue samples and presented an interesting pattern of staining strongly expressed within the stroma and the septal architecture of the tumor. The number of CD56- and CD57-positive lymphocytes identified in tissue samples both from squamous cell carcinoma and from the stroma was statistically significantly lower than that in the reference group. MT expression by tumor cells is thus associated with an aggressive phenotype of the tumor and the ability to create metastases.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vimentina / Carcinoma de Células Escamosas / Neoplasias Faríngeas / Neoplasias de Cabeza y Cuello / Metalotioneína Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2013 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vimentina / Carcinoma de Células Escamosas / Neoplasias Faríngeas / Neoplasias de Cabeza y Cuello / Metalotioneína Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2013 Tipo del documento: Article