A functional BCR in human IgA and IgM plasma cells.
Blood
; 121(20): 4110-4, 2013 May 16.
Article
en En
| MEDLINE
| ID: mdl-23550036
ABSTRACT
Plasma cells (PCs) are terminally differentiated cells of the B-cell lineage that secrete antibodies at a high rate and are thought to lack the expression of the B-cell receptor (BCR). Here, we report that human IgA and IgM, unlike IgG, PCs express a membrane functional BCR associated with the Igα/Igß heterodimer. BCR cross-linking on IgA and IgM PCs led to Ca(2+) mobilization and extracellular signal-regulated kinase 1/2 and AKT phosphorylation and impacted survival of IgA PCs. These findings demonstrate a significant difference between human IgG, IgM, and IgA PCs and suggest that the IgA PC repertoire may be modulated by specific antigens with implications for the regulation of the mucosal immune system.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Plasmáticas
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Inmunoglobulina A
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Inmunoglobulina M
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Receptores de Antígenos de Linfocitos B
Límite:
Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article