Estrogen receptor function and regulation in fish and other vertebrates.
Gen Comp Endocrinol
; 192: 15-24, 2013 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-23583769
ABSTRACT
Estrogens, steroid hormones critically involved in reproductive processes of vertebrates, signal primarily through their intracellular estrogen receptors (ERs). The ERs belong to a superfamily of nuclear receptors that act as ligand inducible transcription factors. Herein, we review what is known about ER structure, subtypes, mechanism(s) of action and auto-regulation by estrogens. Focus is placed on the ER in fish but comparisons are made to mammals and other vertebrates. Finally, we provide context and a proposed model integrating our knowledge on autoregulation of the receptor and its functions in the liver. Future areas of study are suggested, along with cautions when designing experiments, especially for the detection of endocrine disruptors.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vertebrados
/
Receptores de Estrógenos
/
Peces
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2013
Tipo del documento:
Article