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A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase.
Boehr, David D; Schnell, Jason R; McElheny, Dan; Bae, Sung-Hun; Duggan, Brendan M; Benkovic, Stephen J; Dyson, H Jane; Wright, Peter E.
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  • Boehr DD; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Schnell JR; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • McElheny D; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Bae SH; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Duggan BM; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Benkovic SJ; The Pennsylvania State University, Department of Chemistry, 414 Wartik Laboratory, University Park, PA 16802, USA.
  • Dyson HJ; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Wright PE; Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Biochemistry ; 52(27): 4605-19, 2013 Jul 09.
Article en En | MEDLINE | ID: mdl-23758161
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tetrahidrofolato Deshidrogenasa / Aminoácidos / Mutación Idioma: En Año: 2013 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tetrahidrofolato Deshidrogenasa / Aminoácidos / Mutación Idioma: En Año: 2013 Tipo del documento: Article