A method for estimating the residual risk of transfusion-transmitted HBV infection associated with occult hepatitis B virus infection in a donor population without universal anti-HBc screening.
Vox Sang
; 105(4): 290-8, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23802710
ABSTRACT
BACKGROUND AND OBJECTIVES:
This report describes a method for estimating the risk of transfusion-transmitted HBV infection attributable to blood components from donors with occult hepatitis B virus infection (OBI) applicable where universal anti-HBc screening is not performed. MATERIALS ANDMETHODS:
In the context of parallel HBsAg and individual donation HBV DNA testing, we developed a mathematical function p(OBI) to estimate the probability of failing to detect [p(NAT nondetection)] a potentially infectious [p(transmission)] donation from a donor with OBI.RESULTS:
Among 1 312 451 donations tested for HBsAg and HBV DNA, 29 (from 17 anti-HBc reactive donors classified as OBI) were individual donation NAT negative, giving a p(NAT nondetection) of 2·2096 (95 CI 1·538-3·173) × 10(-5) . To date, lookback on OBI donors has identified 35 (8·2%) recipients with evidence of current or past HBV infection among 427 tested recipients. After correcting for the background anti-HBc rate in recipients, this results in a p(transmission) of 0·0384 (0·0167-0·0601). The product, pOBI is 1 in 981 920 (95% CI 437 181-3 223 701). When this is summed with the WP risk for the 2011-2012 period, the overall HBV residual risk estimate is 1 in 538 224 (95% CI 209 732-1 552 443).CONCLUSION:
We estimate the OBI residual risk in Australia is approximately 1 in 982 000 per unit transfused, and this risk represents 55% of the total HBV residual risk and is declining as consequence of ID-NAT identifying repeat donors with OBI.Palabras clave
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Donantes de Sangre
/
Virus de la Hepatitis B
/
Reacción a la Transfusión
/
Hepatitis B
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
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Risk_factors_studies
/
Screening_studies
Límite:
Humans
País/Región como asunto:
Oceania
Idioma:
En
Año:
2013
Tipo del documento:
Article