The 2518 A/G polymorphism in the MCP-1 gene and cancer risk: a meta-analysis.
Asian Pac J Cancer Prev
; 14(6): 3575-9, 2013.
Article
en En
| MEDLINE
| ID: mdl-23886148
ABSTRACT
BACKGROUND:
The 2518 A/G polymorphism in the MCP-1 gene has been extensively studied for associations with cancer; however, results from replication studies have been inconsistent. The aim of this investigation was to determine links with risk of cancer by meta-analysis.METHODS:
We searched Pubmed, Embase, CNKI, Weipu and Wanfang databases, covering all case-control studies until March, 2013. Statistical analyses were performed using the Revman 5.0 software.RESULTS:
A total of 11 case-control studies met our inclusion criteria, including 1,422 cases and 2,237 controls. The results indicated that the MCP-1 2518 gene polymorphism had no association with cancer risk overall (GG vs.GA+ AA OR = 0.89, 95%CI = 0.61-1.28, P = 0.52). However, in the subgroup analysis by ethnicity, a decrease of cancer risk was found in Asian populations (GG vs.GA+ AA OR = 0.79, 95%CI = 0.63-0.99, P = 0.04).CONCLUSION:
This meta-analysis suggested that the 2518A/G polymorphism of MCP-1 gene is associated with risk of cancer among Asian, but not in Caucasian populations.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Quimiocina CCL2
/
Neoplasias
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article