In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites.
Antimicrob Agents Chemother
; 57(11): 5747-54, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23979747
ABSTRACT
Upon the screening of 16 antiproliferative compounds against Toxoplasma gondii and Neospora caninum, two hydrolytically stable ruthenium complexes (compounds 16 and 18) exhibited 50% inhibitory concentrations of 18.7 and 41.1 nM (T. gondii) and 6.7 and 11.3 nM (N. caninum). To achieve parasiticidal activity with compound 16, long-term treatment (22 to 27 days at 80 to 160 nM) was required. Transmission electron microscopy demonstrated the rapid impact on and ultrastructural alterations in both parasites. These preliminary findings suggest that the potential of ruthenium-based compounds should thus be further exploited.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Rutenio
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Toxoplasma
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Neospora
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Complejos de Coordinación
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Estadios del Ciclo de Vida
Límite:
Animals
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Humans
Idioma:
En
Año:
2013
Tipo del documento:
Article