Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 58(1): 574-6, 2014.
Article
en En
| MEDLINE
| ID: mdl-24126586
ABSTRACT
Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Verapamilo
/
Diarilquinolinas
/
Mycobacterium tuberculosis
/
Antituberculosos
Idioma:
En
Año:
2014
Tipo del documento:
Article