Neamine induces neuroprotection after acute ischemic stroke in type one diabetic rats.

Ning, R; Chopp, M; Zacharek, A; Yan, T; Zhang, C; Roberts, C; Lu, M; Chen, J

Ning, R; Chopp, M; Zacharek, A; Yan, T; Zhang, C; Roberts, C; Lu, M; Chen, J.

Afiliación

Ning R; Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Chopp M; Department of Neurology, Henry Ford Hospital, Detroit, MI, USA; Department of Physics, Oakland University, Rochester, MI, USA.
Zacharek A; Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Yan T; Department of Neurology, Henry Ford Hospital, Detroit, MI, USA; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300060, China.
Zhang C; Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Roberts C; Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Lu M; Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI, USA.
Chen J; Department of Neurology, Henry Ford Hospital, Detroit, MI, USA; Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300060, China. Electronic address: jieli@neuro.hfh.edu.

Neuroscience ; 257: 76-85, 2014 Jan 17.

Article en En | MEDLINE | ID: mdl-24211797

Asunto(s)

Diabetes Mellitus Experimental/complicaciones; Framicetina/uso terapéutico; Infarto de la Arteria Cerebral Media/complicaciones; Infarto de la Arteria Cerebral Media/tratamiento farmacológico; Fármacos Neuroprotectores/uso terapéutico; Angiopoyetinas/metabolismo; Animales; Presión Sanguínea/efectos de los fármacos; Barrera Hematoencefálica/efectos de los fármacos; Barrera Hematoencefálica/fisiopatología; Temperatura Corporal/efectos de los fármacos; Caspasa 3/metabolismo; Modelos Animales de Enfermedad; Extravasación de Materiales Terapéuticos y Diagnósticos; Masculino; Proteínas Serina-Treonina Quinasas/metabolismo; Ratas; Ratas Wistar; Receptor para Productos Finales de Glicación Avanzada; Receptores Inmunológicos/metabolismo; Índice de Severidad de la Enfermedad; Factores de Tiempo; Receptor Toll-Like 4/metabolismo; Quinasa de Factor Nuclear kappa B

Palabras clave

Ang1; Angiogenin; BBB; BP; BT; DM; ECA; ECM; IBZ; ICA; MCAo; NFκB; Neamine; PBS; RAGE; T1DM; TLR4; TUNEL; WT; advanced glycation end products receptor; angiopoietin-1; blood pressure; bloodbrain barrier; body temperature; diabetes mellitus; external carotid artery; extracellular matrix; internal carotid artery; ischemic border area; mNSS; middle cerebral artery occlusion; modified neurological severity score; neuroprotection; nuclear factor kappa-light-chain-enhancer of activated B cells; phosphate-buffered saline; stroke; terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling; toll-like receptor 4; type one diabetes; wild type

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Framicetina / Fármacos Neuroprotectores / Infarto de la Arteria Cerebral Media / Diabetes Mellitus Experimental Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2014 Tipo del documento: Article

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