Design, synthesis and biological evaluation of &#945;-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.

Axford, Lorraine C; Agarwal, Piyush K; Anderson, Kelly H; Andrau, Laura N; Atherall, John; Barker, Stephanie; Bennett, James M; Blair, Michael; Collins, Ian; Czaplewski, Lloyd G; Davies, David T; Gannon, Carlie T; Kumar, Dushyant; Lancett, Paul; Logan, Alastair; Lunniss, Christopher J; Mitchell, Dale R; Offermann, Daniel A; Palmer, James T; Palmer, Nicholas; Pitt, Gary R W; Pommier, Stéphanie; Price, Daniel; Narasinga Rao, B; Saxena, Rashmi; Shukla, Tarun; Singh, Amit K; Singh, Mahipal; Srivastava, Anil; Steele, Christopher; Stokes, Neil R; Thomaides-Brears, Helena B; Tyndall, Edward M; Watson, David; Haydon, David J

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.

Axford, Lorraine C; Agarwal, Piyush K; Anderson, Kelly H; Andrau, Laura N; Atherall, John; Barker, Stephanie; Bennett, James M; Blair, Michael; Collins, Ian; Czaplewski, Lloyd G; Davies, David T; Gannon, Carlie T; Kumar, Dushyant; Lancett, Paul; Logan, Alastair; Lunniss, Christopher J; Mitchell, Dale R; Offermann, Daniel A; Palmer, James T; Palmer, Nicholas; Pitt, Gary R W; Pommier, Stéphanie; Price, Daniel; Narasinga Rao, B; Saxena, Rashmi; Shukla, Tarun; Singh, Amit K; Singh, Mahipal; Srivastava, Anil; Steele, Christopher; Stokes, Neil R; Thomaides-Brears, Helena B; Tyndall, Edward M; Watson, David; Haydon, David J.

Afiliación

Axford LC; Biota Holdings Ltd, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia. Electronic address: l.offermann@biota.com.au.

Bioorg Med Chem Lett ; 23(24): 6598-603, 2013 Dec 15.

Article en En | MEDLINE | ID: mdl-24239017

Asunto(s)

Benzotiazoles/química; Benzotiazoles/farmacología; Topoisomerasa de ADN IV/antagonistas & inhibidores; Diseño de Fármacos; Ácidos Isonipecóticos/química; Inhibidores de Topoisomerasa II/síntesis química; Inhibidores de Topoisomerasa II/farmacología; Animales; Antibacterianos/síntesis química; Antibacterianos/química; Antibacterianos/farmacocinética; Antibacterianos/farmacología; Benzotiazoles/síntesis química; Girasa de ADN/química; Girasa de ADN/metabolismo; Topoisomerasa de ADN IV/metabolismo; Enterococcus faecalis/efectos de los fármacos; Enterococcus faecalis/enzimología; Activación Enzimática/efectos de los fármacos; Haemophilus influenzae/efectos de los fármacos; Haemophilus influenzae/enzimología; Semivida; Ratones; Pruebas de Sensibilidad Microbiana; Ratas; Staphylococcus aureus/efectos de los fármacos; Staphylococcus aureus/enzimología; Streptococcus pyogenes/efectos de los fármacos; Streptococcus pyogenes/enzimología; Inhibidores de Topoisomerasa II/química; Inhibidores de Topoisomerasa II/farmacocinética

Palabras clave

Antibacterial; DNA gyrase; Topoisomerase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Topoisomerasa de ADN IV / Benzotiazoles / Inhibidores de Topoisomerasa II / Ácidos Isonipecóticos Límite: Animals Idioma: En Año: 2013 Tipo del documento: Article

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