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Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction.
Buragohain, Pori; Saikia, Bishwajit; Surineni, Naresh; Barua, Nabin C; Saxena, Ajit K; Suri, Nitasha.
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  • Buragohain P; Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
  • Saikia B; Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
  • Surineni N; Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
  • Barua NC; Natural Products Chemistry Division, CSIR-North-East Institute of Science & Technology, Jorhat 785006, Assam, India.
  • Saxena AK; Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India.
  • Suri N; Pharmacology Division, Indian Institute of Integrative Medicine, Jammu 180001, India.
Bioorg Med Chem Lett ; 24(1): 237-9, 2014 Jan 01.
Article en En | MEDLINE | ID: mdl-24332623
ABSTRACT
A series of C-10 acetal artemisinin dimers were synthesized using Sonogashira cross-coupling reaction. All these novel semisynthetic artemisinin dimers exhibited excellent growth inhibitory activity against Lung A-549 human cancer cell line.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Artemisininas / Antineoplásicos Límite: Humans Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Artemisininas / Antineoplásicos Límite: Humans Idioma: En Año: 2014 Tipo del documento: Article