Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands.
Sci Rep
; 4: 3881, 2014 Jan 24.
Article
en En
| MEDLINE
| ID: mdl-24457553
ABSTRACT
The present study examined the effects of administering selective 5-HT antagonists and agonists to rats tested in the elevated zero-maze (EZM) model of anxiety. The EZM paradigm has advantages over the elevated plus-maze (EPM) paradigm with respect to measuring anxiety, yet has been utilized less frequently. Three experiments were conducted each with a diazepam control (0.25, 0.5 and 0.75â
mg/kg). In the first experiment, we administered the 5-HT2C antagonist RS 102221 (0.5, 1.0, and 2.0â
mg/kg) and 5-HT2C agonist MK-212 (0.25, 0.5 and 0.75â
mg/kg); in the second experiment, we administered the 5-HT3 antagonist Y-25130 (0.1, 1.0 and 3.0â
mg/kg) and 5-HT3 agonist SR 57227A (0.1, 1.0 and 3.0â
mg/kg), and in the third experiment, we administered the 5-HT4 antagonist RS 39604 (0.01, 0.1, 1.0â
mg/kg) and 5-HT4 agonist RS 67333 (0.01, 0.1 and 0.5â
mg/kg). The administration of 5-HT2/3/4 subtype antagonists all generated behavioral profiles indicative of anxiolytic-like effects in the EZM, which was apparent from examination of both traditional and ethological measures. While little effect was observed from 5-HT2 and 5-HT3 agonists, the 5-HT4 agonist RS 67333 was found to produce a paradoxical anxiolytic-like effect similar to that produced by the 5-HT4 antagonist RS 39604. We conclude by discussing the implications of these findings.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Antagonistas de la Serotonina
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Ansiolíticos
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Agonistas de Receptores de Serotonina
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Aprendizaje por Laberinto
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2014
Tipo del documento:
Article