A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.
Bioorg Med Chem
; 22(7): 2269-79, 2014 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-24618511
ABSTRACT
Therapeutic treatment of AIDS is recently characterized by a crescent effort towards the identification of multiple ligands able to target different steps of HIV-1 life cycle. Taking into consideration our previously obtained SAR information and combining some important chemical structural features we report herein the synthesis of novel benzyl-indole derivatives as anti-HIV agents. Through this work we identified new dual target small molecules able to inhibit both IN-LEDGF/p75 interaction and the IN strand-transfer step considered as two crucial phases of viral life cycle.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Replicación Viral
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VIH-1
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Inhibidores de Integrasa
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Integrasa de VIH
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Fármacos Anti-VIH
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Péptidos y Proteínas de Señalización Intercelular
Tipo de estudio:
Prognostic_studies
Idioma:
En
Año:
2014
Tipo del documento:
Article