The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites.
Mutat Res
; 213(2): 117-24, 1989 Aug.
Article
en En
| MEDLINE
| ID: mdl-2474762
ABSTRACT
The restriction endonuclease MspI (cleavage site C/CGG) induces chromosomal breaks in human lymphocytes. The breakpoints are distributed non-randomly along the chromosomes and the pattern of MspI-induced breakage depends on the recovery time (20 h or 6 h). Chromosomal bands preferentially involved in breakage are likely to coincide with bands where common fragile sites are located.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Desoxirribonucleasas de Localización Especificada Tipo II
/
Aberraciones Cromosómicas
/
Fragilidad Cromosómica
Límite:
Humans
Idioma:
En
Año:
1989
Tipo del documento:
Article