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Differential expression of stromal aromatase in obese females is regulated by DNA methylation.
Zeng, Xian-Cheng; Ao, Xiang; Yang, Hai-Feng; Zhang, Guang-Xian; Li, Wen-Hong; Liu, Qi-Long; Tang, Yue-Liang; Xie, Yi-Cheng; He, Wen-Guang; Huang, Yan-Nian; Zhang, Lei; Li, Rong-Jiang.
Afiliación
  • Zeng XC; Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
  • Ao X; Department of Breast Surgery, The Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou 510095, P.R. China.
  • Yang HF; Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou 510120, P.R. China.
  • Zhang GX; School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China.
  • Li WH; Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
  • Liu QL; Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
  • Tang YL; Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
  • Xie YC; Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
  • He WG; Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
  • Huang YN; Department of General Surgery, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
  • Zhang L; Department of Clinical Laboratory, Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-Sen University), Zengcheng 511300, P.R. China.
  • Li RJ; Department of General Surgery, Affiliated Xixiang People's Hospital of Guangdong Medical College, Shenzhen 518102, P.R. China.
Mol Med Rep ; 10(2): 887-90, 2014 Aug.
Article en En | MEDLINE | ID: mdl-24866503
ABSTRACT
Obesity increases the incidence, progression and mortality of breast cancer among postmenopausal females. This is partly due to excessive estrogen production in the adipose tissue of obese females. Aromatase is a key enzyme in estrogen biosynthesis. In the current study, the tensional force­triggered inducibility of aromatase expression was observed to vary in ASCs isolated from different disease­free individuals. In addition, this phenomenon was associated with the activation of the aromatase PII promoter and its DNA methylation load. These findings highlight the impact of tensional forces on estrogen biosynthesis in obese females.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aromatasa / Tejido Adiposo / Metilación de ADN Límite: Female / Humans Idioma: En Año: 2014 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aromatasa / Tejido Adiposo / Metilación de ADN Límite: Female / Humans Idioma: En Año: 2014 Tipo del documento: Article