Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate).

Abe, Hiroyuki; Kikuchi, Shinichi; Hayakawa, Kazuhide; Iida, Tetsuya; Nagahashi, Noboru; Maeda, Katsuya; Sakamoto, Johei; Matsumoto, Noriaki; Miura, Tomoya; Matsumura, Koji; Seki, Noriyoshi; Inaba, Takashi; Kawasaki, Hisashi; Yamaguchi, Takayuki; Kakefuda, Reina; Nanayama, Toyomichi; Kurachi, Hironori; Hori, Yoshikazu; Yoshida, Takayuki; Kakegawa, Junya; Watanabe, Yoshihiro; Gilmartin, Aidan G; Richter, Mark C; Moss, Katherine G; Laquerre, Sylvie G

Abe, Hiroyuki; Kikuchi, Shinichi; Hayakawa, Kazuhide; Iida, Tetsuya; Nagahashi, Noboru; Maeda, Katsuya; Sakamoto, Johei; Matsumoto, Noriaki; Miura, Tomoya; Matsumura, Koji; Seki, Noriyoshi; Inaba, Takashi; Kawasaki, Hisashi; Yamaguchi, Takayuki; Kakefuda, Reina; Nanayama, Toyomichi; Kurachi, Hironori; Hori, Yoshikazu; Yoshida, Takayuki; Kakegawa, Junya; Watanabe, Yoshihiro; Gilmartin, Aidan G; Richter, Mark C; Moss, Katherine G; Laquerre, Sylvie G.

Afiliación

Abe H; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Kikuchi S; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Hayakawa K; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Iida T; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Nagahashi N; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Maeda K; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Sakamoto J; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Matsumoto N; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Miura T; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Matsumura K; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Seki N; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Inaba T; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Kawasaki H; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Yamaguchi T; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Kakefuda R; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Nanayama T; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Kurachi H; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Hori Y; Central Pharmaceutical Research Institute, Japan Tobacco, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Yoshida T; Pharmaceutical Frontier Research Laboratory, Japan Tobacco, 1-13-2 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Kakegawa J; Pharmaceutical Frontier Research Laboratory, Japan Tobacco, 1-13-2 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Watanabe Y; Pharmaceutical Frontier Research Laboratory, Japan Tobacco, 1-13-2 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Gilmartin AG; Oncology R&D, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.
Richter MC; Oncology R&D, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.
Moss KG; Oncology R&D, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.
Laquerre SG; Oncology R&D, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.