Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

Pei, Zhonghua; Blackwood, Elizabeth; Liu, Lichuan; Malek, Shiva; Belvin, Marcia; Koehler, Michael F T; Ortwine, Daniel F; Chen, Huifen; Cohen, Frederick; Kenny, Jane R; Bergeron, Philippe; Lau, Kevin; Ly, Cuong; Zhao, Xianrui; Estrada, Anthony A; Truong, Tom; Epler, Jennifer A; Nonomiya, Jim; Trinh, Lan; Sideris, Steve; Lesnick, John; Bao, Linda; Vijapurkar, Ulka; Mukadam, Sophie; Tay, Suzanne; Deshmukh, Gauri; Chen, Yung-Hsiang; Ding, Xiao; Friedman, Lori S; Lyssikatos, Joseph P

Pei, Zhonghua; Blackwood, Elizabeth; Liu, Lichuan; Malek, Shiva; Belvin, Marcia; Koehler, Michael F T; Ortwine, Daniel F; Chen, Huifen; Cohen, Frederick; Kenny, Jane R; Bergeron, Philippe; Lau, Kevin; Ly, Cuong; Zhao, Xianrui; Estrada, Anthony A; Truong, Tom; Epler, Jennifer A; Nonomiya, Jim; Trinh, Lan; Sideris, Steve; Lesnick, John; Bao, Linda; Vijapurkar, Ulka; Mukadam, Sophie; Tay, Suzanne; Deshmukh, Gauri; Chen, Yung-Hsiang; Ding, Xiao; Friedman, Lori S; Lyssikatos, Joseph P.

Afiliación

Pei Z; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Blackwood E; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Liu L; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Malek S; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Belvin M; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Koehler MF; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Ortwine DF; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Chen H; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Cohen F; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Kenny JR; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Bergeron P; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Lau K; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Ly C; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Zhao X; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Estrada AA; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Truong T; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Epler JA; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Nonomiya J; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Trinh L; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Sideris S; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Lesnick J; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Bao L; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Vijapurkar U; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Mukadam S; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Tay S; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Deshmukh G; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Chen YH; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Ding X; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Friedman LS; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Lyssikatos JP; Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.