[MicroRNA expression profiles in squamous cell carcinomas of the meso- and hypopharynx]. / Mikro-RNS-expressziós mintázatok mesopharynx-hypopharynx laphámcarcinomákban.
Orv Hetil
; 155(27): 1063-70, 2014 Jul 06.
Article
en Hu
| MEDLINE
| ID: mdl-24974841
ABSTRACT
INTRODUCTION:
MicroRNAs play a role in carcinogenesis through their genome regulatory function.AIM:
The aim of the authors was to identify and compare microRNA expression signatures of meso- and hypopharynx squamous cell cancers on the basis of the cancer field hypothesis.METHOD:
Using standard mapping biopsy (tumour tissue and macroscopically normal tissues obtained 1, 2 and 3 cm from margin) 13 snap frozen sample series were analysed for microRNA expression with quantitative real-time polymerase chain reaction.RESULTS:
MiR-221 was significantly overexpressed in mesopharynx cancers, whole miR-21, miR-143 and miR-155 showed significant overexpression in hypopharynx cancers.CONCLUSIONS:
Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
/
Neoplasias Faríngeas
/
MicroARNs
/
Transcriptoma
Tipo de estudio:
Risk_factors_studies
/
Screening_studies
Límite:
Humans
Idioma:
Hu
Año:
2014
Tipo del documento:
Article