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Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.
Takeo, Koji; Tanimura, Shun; Shinoda, Takehiro; Osawa, Satoko; Zahariev, Ivan Krasmirov; Takegami, Naoki; Ishizuka-Katsura, Yoshiko; Shinya, Naoko; Takagi-Niidome, Shizuka; Tominaga, Aya; Ohsawa, Noboru; Kimura-Someya, Tomomi; Shirouzu, Mikako; Yokoshima, Satoshi; Yokoyama, Shigeyuki; Fukuyama, Tohru; Tomita, Taisuke; Iwatsubo, Takeshi.
Afiliación
  • Takeo K; Departments of Neuropathology and Neuroscience and.
  • Tanimura S; Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, and.
  • Shinoda T; RIKEN Systems and Structural Biology Center andDivision of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan;
  • Osawa S; Departments of Neuropathology and Neuroscience and.
  • Zahariev IK; Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, and.
  • Takegami N; Departments of Neuropathology and Neuroscience andFaculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;
  • Ishizuka-Katsura Y; RIKEN Systems and Structural Biology Center andDivision of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan;
  • Shinya N; RIKEN Systems and Structural Biology Center andDivision of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan;
  • Takagi-Niidome S; Departments of Neuropathology and Neuroscience and.
  • Tominaga A; Departments of Neuropathology and Neuroscience and.
  • Ohsawa N; RIKEN Systems and Structural Biology Center andDivision of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan;
  • Kimura-Someya T; RIKEN Systems and Structural Biology Center andDivision of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan;
  • Shirouzu M; RIKEN Systems and Structural Biology Center andDivision of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan;
  • Yokoshima S; Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, and.
  • Yokoyama S; RIKEN Systems and Structural Biology Center andRIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan; and.
  • Fukuyama T; Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, and.
  • Tomita T; Departments of Neuropathology and Neuroscience andCore Research for Evolutional Science and Technology, Japan Science and Technology Agency, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan taisuke@mol.f.u-tokyo.ac.jp.
  • Iwatsubo T; Departments of Neuropathology and Neuroscience andFaculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Proc Natl Acad Sci U S A ; 111(29): 10544-9, 2014 Jul 22.
Article en En | MEDLINE | ID: mdl-25009180
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Secretasas de la Proteína Precursora del Amiloide / Imidazoles Límite: Humans Idioma: En Año: 2014 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Secretasas de la Proteína Precursora del Amiloide / Imidazoles Límite: Humans Idioma: En Año: 2014 Tipo del documento: Article